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The activation of the Nrf2 (nuclear factor erythroid-derived 2)/ARE (antioxidant response elements) pathway is likely a principal and underlying mechanism of hormesis, which can limit age-related damage, numerous disease processes progression, and induction of toxicities due to chemicals and radiations (70)

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Bhatia K, Elmarakby AA, El-Remessy AB, Sullivan JC

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NAC treatment increased aortic GSH content, lowered the GSSG/GSH ratio and malondialdehyde levels, and protected against peroxynitrite-induced endothelial dysfunction in both WKY rats and SHRs (24)