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Therefore, reducing the expression of ACSL 4 and LPCAT 3 can decrease the accumulation of intracellular lipid peroxides and inhibit ferroptosis ( Autophagy is a fundamental cellular homeostatic program, and excessive autophagy may trigger cell death, also known as autophagy-dependent cell death ( 4 ) ( 4 expression ( 4 mediates the degradation of ferritin after combining with ferritin heavy chain 1 (FTH 1 ) as a selective autophagic receptor and converts ferritin-bound iron into free iron, thereby inducing ferroptosis ( Figure 1 )
D.GurwitzD.AronovichR.HantaiD.et al
These developments point to a progressive strategy, as reducing inflammation may lessen symptoms frequently linked to elevated inflammatory cytokines in patients with PCOS
Khalifa SAM, Shedid ES, Saied EM, Jassbi AR, Jamebozorgi FH, Rateb ME, et al
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