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doi:10.1042/bj2640437

Resveratrol improves health and survival of mice on a highcalorie diet

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The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

The animals were within 10 % of ideal BCS, and the diets provided were at levels to maintain ideal BCS throughout the study