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Affected adipose depots develop sustained mitochondrial defects and heightened oxidative stress, which amplify existing metabolic disruptions ( 4.2 ER stress and the unfolded protein response The ER contains numerous quality control pathways that regulate protein processing and maintain cellular homeostasis through distinct molecular mechanisms

Tsc2 mediates cellular energy response to control cell growth and survival

Folate supports hormone production through methylation pathways that protect testosterone synthesis from oxidative damage and cellular stress

Science 321 , 117120 (2008)

Patients treated with clonidine report bradycardia and atrioventricular dissociation, while patients treated with moxonidine have increased mortality compared to patients receiving a placebo