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[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Fechtner S, Allen BE, Chriswell ME, Jubair WK, Robertson CE, Kofonow JN, Frank DN, Holers VM, Kuhn KA

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"Scholar Rock Announces Positive 12-Month Top-Line Results From the TOPAZ Phase 2 Clinical Trial Evaluating Apitegromab in Patients With Type 2 and Type 3 Spinal Muscular Atrophy (SMA)"

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Whats more, Inhibitors of RAS must be used with caution in patients with advanced CKD (stages 4, 5), because they can lead to hyperkalemia, acute declines in estimated glomerular filtration rate (eGFR) (Leon and Tangri, 2019)

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