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Thus, by promoting intimal hyperplasia, these vascular disorders (which are related to smooth muscle cell proliferation, collagen accumulation, and the extracellular matrix modification that may result from homocysteinylation of the vascular wall structure leading to connective tissue deterioration) might contribute to the atherogenic tendency of hyperhomocysteinemia

doi: 10.1016/j.lanepe.2021.100142

Growth is further accelerated by rapid expansion within the pharmaceutical, food additive, and cosmetics industries, alongside increasing prevalence of lifestyle-induced diseases and urban air quality concerns that heighten consumer interest in antioxidant protection and cellular health support

Key publications include the original characterization study (PubMed: 930790), stress response research (PubMed: 7540925), and neuroendocrine effects (PubMed: 2547858)