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Ghrelin is a central orexigenic peptide hormone in human energy homeostasis that is also known as hunger hormone and signals through its GPCR, GHSR

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Thus, adequate treatment for obesity is necessary, including lifestyle changes (diet adequation and physical activity) and pharmacotherapy

The reviewed studies demonstrate that ASD-like behavioral deficits in preclinical models can be modulated through interventions targeting diverse biological systems, including neurotransmission, neuroinflammation, metabolism, and the gut-brain axis