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SASP includes pro-inflammatory cytokines (IL-6, IL-8, TNF-), growth factors, and matrix metalloproteinases (MMPs), influencing the tissue microenvironment.19 While SASP plays roles in wound healing and tumor suppression, chronic SASP contributes to inflammation, fibrosis, and aging-related diseases.20 Epigenetic Regulation of Senescence: Chromatin remodeling through histone modifications and DNA methylation influences senescence

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10.1074/jbc.M111.327031 [DOI] [PMC free article] [PubMed] [Google Scholar] 82.OConnell RM, Rao DS, Chaudhuri AA, Boldin MP, Taganov KD, Nicoll J, et al