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At the heart of this metabolic collapse is the direct interference of mHTT with the function of PGC-1, the master transcriptional coactivator of mitochondrial biogenesis and oxidative metabolism [99]

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The production of Lac-Phe autonomously increases in macrophages and intestinal epithelial cells in a cytosolic non-specific dipeptidase 2 (CNDP2)-dependent manner, where CNDP2 is a major Lac-Phe biosynthetic enzyme (Xiao et al., 2023)

Results of a double-blind crossover trial