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The transcriptional responses to oxidative stress induce a set of antioxidant enzyme-encoding genes, in addition to genes that encode components of the glutathione/glutaredoxin (GSH, TTR) and thioredoxin (TSA, TRX, TRR) systems, which play critical roles in repairing oxidatively damaged proteins, protein folding, and sulfur metabolism (Missall et al., 2004

Cell Death Differ 16 , 13031314 (2009)

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As per Walker, the efficacy of MGF in the brain is age-dependent , as the mice in the study had shown better outcomes initially and over the long term if the peptide over-expression occurred earlier in life
