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doi: 10.3390/diagnostics9030082 77 MetzRDuhadawayJBKamasaniULaury-KleintopLMullerAJPrendergastGC

(A) GLP-1 can induce fibronectin type III domain-containing protein 5 (FNDC5) expression in pancreatic -cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT)

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1 It is hypothesized that occlusion, dilation, and rupture of the hair follicle, along with the resulting inflammation, lead to the symptomatology of HS