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Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)

EDTA (Chempur, Piekary lskie, Poland)

The pronounced effects of both medications are typically seen over the long term as the dosage is increased gradually

It may be more painful, but it delivers the drug faster

The elevation of these two reward system neurotransmitters (dopamine and serotonin) has resulted in BPC-157 producing antidepressant effects in some of our patients