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In certain regions of the world, marginal or subclinical vitamin B 12 deficiency may be fairly common in other age groups as well, including children, premenopausal women, and pregnant women, primarily due to low intake of animal-source foods (reviewed in 5)

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It modulates GABA receptors (the same system benzodiazepines target) but without suppressing cognitive function or creating dependence

The folate-cobalamin interaction is pivotal for normal synthesis of purines and pyrimidines and the transfer of the methyl group to cobalamin is essential for the adequate supply of tetrahydrofolate, the substrate for metabolic steps that require folate