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This paper introduces the research progress of research methods of Baijiu flavor chemistry, perception and interaction of flavor compounds, health function factors and other aspects, especially the new hot spots and discoveries in flavor and health research in the past five years, and summarized the latest application of machine learning (ML) and electroencephalogram (EEG) technology in Baijiu flavor research, and the expansion of Baijiu in health function, aiming to provide further reference for the improvement of Baijiu flavor and health quality