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This is further supported by improved outcomes in the matched cohort comparisons within the study group relative to the control group

Unlike true allergic reactions, these side effects stem from the supplement's direct effects on the body rather than an immune system response

NOC compounds have the ability to interact with the DNA of colon cells, leading to the formation of mutagenic substances like O 6 -methylguanine (O 6 -MeG) and O 6 -carboxymethylguanine (O 6 -CMG)

The origin and metabolism of TMAU are illustrated in [Table/Fig-1] [4,6,8-10]