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recent guidelines affirm its use (e.g., AHA updates, StatPearls reviews)

However, their clinical application requires rigorous evaluation of therapeutic efficacy, comprehensive safety profiling, and well-defined patient selection criteria

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doi: 10.1016/j.bcp.2021.114651 [DOI] [PubMed] [Google Scholar] 57.Mandal R, Kohoutova K, Petrvalska O, et al

doi: 10.3389/fnins.2025.1655348 Received 03 July 2025 Accepted 01 October 2025 Published 30 October 2025 Volume 19 - 2025 Edited by Kazuhiko Sawada, Tsukuba International University, Japan Reviewed by Franois Iris, BM-Systems, France Darlan Gusso, Instituto Butantan, Brazil Updates Copyright 2025 Chintalapally, Rajanala and Upadhyay