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Finally, it may be useful to compare docking interacttion energies observed from modelling studies using either the single GSTP1 subunit or the enzyme dimer as template

For example, the signaling kinase PKGI is activated upon dimerization which is enforced when a disulfide bond is formed between the same Cys residue (Cys42 and Cys42) on two different subunits (implying the oxidation of Cys42 in one subunit to sulfenic acid, then condensation with another subunit as the other Cys42 thiol group approaches) [115]

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Mechanistically, the FH / sensitivity to ferroptosis has been attributed to dysfunctional GPX4, the primary cellular defender against ferroptosis [109]

The technique of FNA, and US-guided FNA, is described above in Chapter 6