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Testing the affinity of the ligand to the target molecule may be a necessary initial step before purification since extremely low or high affinity can significantly reduce yield
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In addition to the interplay of IRE1 with JNK, its RIDD activity is also associated with proapoptotic effects, e.g., through the cleavage of miR-17 and other miRNAs to relieve the suppression of TXNIP and CASP2
Quarato, G
