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Several studies using animal models and the strategy of GSH depletion by buthionine sulfoximine as an inhibitor of -GCS demonstrated an increase in oxidative stress markers in the liver and various other organs in vivo [22], and the treatment of cells with GSH or N-acetylcysteine limits such damage and renders cells or tissues less susceptible to oxidative stress [23]

N-Acetylcysteine (NAC) in Schizophrenia Resistant to Clozapine: A Double-Blind, Randomized, Placebo-Controlled Trial Targeting Negative Symptoms

Fantozzi, F

The importance of GSH in cancer treatment is best illustrated by the fact that BSO, the irreversible inhibitor of GCL, is now often used as an adjuvant chemotherapeutic agent to sensitize tumor cells to the effects of chemotherapy (Reber et al., 1998

Research progress on the role of PKM2 in the immune response