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The multidrug efflux regulator AcrR of escherichia coli responds to exogenous and endogenous ligands to regulate efflux and detoxification

Inhibition of the PI3K/mTOR pathway in breast cancer to enhance response to immune checkpoint inhibitors in breast cancer

The naturally occurring Growth Hormone Releasing Hormone is manufactured in the brains hypothalamus, a sort of command center, that then sends signals to the pituitary gland as a secretagogue, which regulates how much of the growth hormone the pituitary gland should release

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In most tumors, infiltrating macrophages are dominated by M2 types, which secrete anti-inflammatory molecules (such as IL-10 and TGF-) to help shape immunosuppressive TME (158)