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Hair, skin, and nails: B12 supports cell reproduction, so hair, skin, and nail health can suffer when levels are low

Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the alox15 gene does not rescue such knock-in mice
Nature Reviews Disease Primers

Treatment is often initiated at a high dose, followed by a maintenance dose given less frequently, as determined by the patient's B12 levels and clinical response

[DOI] [PMC free article] [PubMed] [Google Scholar] Knatchbull FB, Slaughter JC