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Current CSC studies often rely on in vitro 2D cell cultures, which fail to accurately mimic the TME

However, human clinical trials are limited and hence, this peptide should not be regarded as a treatment for cancer

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In addition, HIV-1 Tat inhibits autophagy and proteasomal degradation in microglia and astrocytes, which in turn modulates EV biogenesis pathways and may amplify intercellular propagation of inflammatory signals [58, 59]

To further probe the catalytic mechanism of arGSTs, we conducted quantum mechanics/molecular mechanics (QM/MM) calculations based on the ternary complex of GSH, ()-catechin ( 12 ) and Pt GSTF8