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The review confirmed that animal and human studies demonstrate adequate protein nutrition is crucial for maintenance of GSH homeostasis, and that enteral or parenteral cystine, methionine, N-acetyl-cysteine, and L-2-oxothiazolidine-4-carboxylate are effective cysteine precursors for tissue GSH synthesis

Inhibition of GCL with buthionine sulfoximine (BSO) depleted glutathione rapidly, reflecting its short half-life (1-4 h) as a substrate of multiple enzymes (Fig

In order to minimise the amount of SAM that is lost in this process, methylcobalamin is today obtained directly in supplements

doi: 10.1046/j.1365-313x.2003.01819.x

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