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Tumor Suppressor / Anti-Metastatic Signaling The KISS1 gene product was originally identified as a metastasis suppressor in melanoma and breast cancer cell line models, with loss of KISS1 expression correlating with metastatic progression

BPC-157 promotes angiogenesis through the Egr-1/NAB2 regulatory loop, which simultaneously activates vessel growth (Egr-1) and provides an internal brake (NAB2) to prevent disorganized growth

[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Zalfa C, Paust S

Continued use is required to maintain gains

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