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Knockdown of HIF-1 significantly increases intracellular ROS and apoptosis levels (Xu, 2018), likely through the upregulation of anti-apoptotic factors or modulation of metabolic pathways

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Immunol Invest 51(3):602618 Kim Y, Chongviriyaphan N, Liu C, Russell RM, Wang X-D (2012) Combined -tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets