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However, in clinical trials targeting severe cognitive impairment, chronic fatigue syndrome, or neuropathy, therapeutic doses usually range from 1,500 mg to 3,000 mg (1.5g 3g) daily

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In mice with intact gut microbiota, dietary supplementation of TMAO, carnitine, or high choline can significantly reduce the reverse transport of cholesterol in the body, thereby aggravating the progression of atherosclerosis in mice (35)

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Table 1: Table 2: Rectal and colon cancers related deaths are estimated to be in 60% and 71.5% respectively in 2035), making CRC a worldwide public health concern [35]