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Encarnacin-Rosado, J., Sohn, A

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A more clinically relevant consideration involves metabolic and hormonal interplay : Significant weight loss induced by retatrutide may alter sex hormone-binding globulin (SHBG) levels, which in turn affects the ratio of free to total testosterone

8 Conclusion PCOS is fundamentally characterized by interconnected pathological axes encompassing dysregulated glucose-lipid metabolism (manifesting as IR and obesity), HA, chronic inflammation with oxidative stress, and ovulatory dysfunction