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as a key regulator of mitochondrial biogenesis, PGC1 enhances mitochondrial function in myoblasts, supplies sufficient energy for differentiation, and regulates the transcription of myogenic genes to accelerate myotube maturation

Overall, these studies highlight the role of adipocyte lipolysis in inter-organ crosstalk through the release of lipid signals and EVs to regulate whole body tissue homeostasis (Figure 4)

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doi: 10.1056/NEJMoa0909809

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