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A randomized controlled trial in 2018 showed that omega-3 supplementation altered gene expression of the following genes

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Mirtazapine, which increases the release of serotonin and noradrenaline, thus exerting antidepressant effects, appears to be one of the drugs that most helps fibromyalgia patients improve sleep, pain, and quality of life [93]

On the other hand, testosterone may increase male vulnerability to an adverse illness course compared to estrogen 56 , attributed to its narrower and sometimes unfavorable neuroprotection and neurotransmitter modulation profile 57

7.4.2 Emerging therapeutic dilemmas in DM-pulmonary comorbidity management While the causal relationship between DM and pulmonary disorders remains incompletely elucidated, the clinical management of their comorbid status presents emerging challenges