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* Correspondence: Sichong Ren, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This initial angiogenic burst is largely mediated by the vascular endothelial growth factor (VEGF) that is greatly produced on granulosa-lutein cells and theca-lutein cells due to luteinizing hormone (LH) and hypoxia-inducible factors (HIF-1)

The organic phase and the non-solvent phase are pumped through a static mixer into a non-solvent quench liquid, such as heptane

Numerous exogenous antioxidant molecules (nutritional antioxidants) have been shown to play an important role in excessive ROS accumulation in organisms