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Moreover, molecules, such as chemokines, cytokines, growth factors, adenosine, glycosaminoglycans, non-coding RNAs, and cellular processes including oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, hypoxia, and alternative polyadenylation have been linked with IPF development

Thus, the FIGHT RP study showed that oral NAC is safe in patients with RP, with a maximum tolerated dose of 1800 mg twice daily that resulted in good intraocular levels

Given its broad spectrum of activity and the established evidence of its efficacy, selenium holds considerable promise as a therapeutic agent in the clinical management of cancer

Main Study Findings and Authors Conclusions Table 8Summary of Findings Included Systematic Review and Meta-Analysis OR = Odds Ratio, CI = Confidence Interval, RRR = Relative Risk Reduction, NNT = Number Needed to Treat Table 9Summary of Findings of Included Non-Randomized Study Table 10Summary of Recommendations of Included Guidelines RCT = Randomized Controlled Trial, CI = Confidence Interval Appendix 5

Targets 15 , 10561063 (2014)