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Other miRNAs, like miR-15, miR-20a/b, or miR-101 modulate cell cycle and senescence pathways, often targeting epigenetic regulators like EZH2, thus contributing to UV-induced aging and tumor suppression mechanisms 109

Melatonin can also influence mitochondria-dependent apoptotic processes by interfering with the release of ROS, cytochrome c, and cell death regulatory proteins [47]

Experimentally, this relationship has been verified in breast cancer patients with an r 2 of 0.6262 [30], supporting its use as a surrogate marker of low global GSH states in general

This process is typically observed in metal complexes, catalytic nanoplatforms, or enzyme-facilitated electron transfer systems, rather than as a simple direct reaction of free GSH with metal ions