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88 The authors of a separate cross-sectional study suggest the impact of metformin on lowering vitamin D levels may have been confounded by use of supplements at the time of diagnosis

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Oral supplementation of B12, unlike the injection, must be given every day

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People at risk of decreased absorption (elderly, inflammatory bowel disease, gastric resection or autoimmune conditions)

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Its ~5day halflife allows convenient onceweekly subcutaneous dosing [1]

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