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CB-839 is now under investigation in phase I/II clinical trials in a range of solid and hematologic malignancies (Table 2)

ROS, which include superoxide anion radicals, hydrogen peroxide, and hydroxyl radicals, can interact with membrane lipids and DNA to produce toxic metabolites containing lipid peroxides, carbonyls, and epoxides [37]

La sua funzione primaria cruciale per il metabolismo energetico, agendo come "navetta" che trasporta gli acidi grassi a catena lunga all'interno dei mitocondri, le centrali energetiche delle cellule

Together, these agents represent a broader shift toward combining mitochondrial vulnerabilities with upstream molecular drivers to improve CRC outcomes [157, 158]

doi: 10.1042/BJ20040974