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Selinexor inhibits XPO1 and has been approved for the treatment of patients with relapsed/refractory multiple myeloma after one to three prior lines of therapy in combination with bortezomib or pomalidomide with dexamethasone, or after 3 prior lines with dexamethasone alone

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Based on the encouraging clinical response seen with daratumumab-Kd in EQUULEUS [74], a phase III study (CANDOR) was conducted to further evaluate daratumumab-Kd in RRMM patients who had received 13 prior therapy lines [75]