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Despite the imbalance between Smad3 and Notch in aging muscle, there are evidence to suggest that old satellite cells retain the capacity to self renew [23], and regenerate muscles upon injury[24]
A., Zhang, Y., Nunes-Nesi, A., Fernie, A
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[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Shih A.Y., Johnson D.A., Wong G., Kraft A.D., Jiang L., Erb H., Johnson J.A., Murphy T.H
Also, chronic circadian misalignment leads to immune suppression and low-grade systemic inflammation, both of which contribute to impaired tumor immunosurveillance 146
