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In addition, 27-OHC have also been demonstrated to induce cellular cytotoxicity by increasing ROS production and downregulating antioxidant enzymes (rGSH, GSH-Px and tSOD)

[DOI] [PubMed] [Google Scholar] 56.Austgen T.R., Chakrabarti R., Chen M.K., Souba W.W

Zhang L, Chen J, Yan L, He Q, Xie H, Chen M

The visualization correctly shows how the negatively charged platencin moieties are positioned to favorably interact with electrostatic forces in the positively charged binding pocket to form an energetically favorable complex, which plays a major role in the binding stability and specificity of this molecular interaction

Here, the inhibition of wounding-induced ROS accumulation significantly inhibited healing in planarian worms by preventing F-actin reorganisation and epithelial cell rearrangements mediated through c-JUN activation at the wound site 122