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The commercial Fe 3 O 4 nanoparticles, the carbon supports (C) synthesized via the similar process without Hb, the porous carbon supports (pC) obtained using bull serum albumin (BSA) as template and the heme-derived single-atom Fe-N 4 catalysts through pyrolysis (FeSAN) were synthesized as references (Supplementary Figs

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Then, the solution was given to the mice at the dosage of 10 mg/kg