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Description
This may be further pronounced in patients with diabetes with compromised gastrointestinal function due to autonomic neuropathy
Furthermore, participants in these studies did not discontinue use due to serious side effects, highlighting its low-risk profile
However, this phenomenon is not universally exhibited by all ADCs, as its manifestation depends critically on the physicochemical properties and membrane permeability of the conjugated cytotoxic agent
Research has discovered that the accumulation of -2HG caused by IDH1 mutations can inhibit the amino transferases branched-chain aminotransferase 1 and branched-chain aminotransferase 2, reducing glutamate levels and increasing the synthesis of glutathione, thereby affecting tumor cell survival [149]
Biomolecules, 11(11), 1723
