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These include: Metformin (commonly prescribed for diabetes) Proton pump inhibitors (PPIs) H2-receptor blockers Regular or long-term antacid use These medications reduce stomach acid or affect how vitamin B12 is transported and absorbed in the intestine

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Recent studies have shown that plant cells can only generate pseudo-B12, they do not have the same effect and can even compete with B12 for the same cellular receptors, as a result of which B12 can no longer do its job properly