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Metallomics-metabolomics studies have revealed key mechanisms by which metals contribute to metabolic disorders ( 7 Conclusion This perspective paper highlights the evolving understanding of metal exposure as a significant concern in toxicology and public health, emphasizing the necessity to move towards an innovative paradigm which highlights the concept of multiple metal co-exposure in contributing to the development of a set of chronic pathologies in humans

Direct impact can damage fragile structures and cause foaming that indicates peptide denaturation

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A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis

R.Erdjument-BromageH.FerrisC
