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Enlarged adipocytes alter expression and secretion of adipokines leading to the increased production of inflammatory cytokines such as TNF- and reduced production of adiponectin, an anti-inflammatory adipokine (Kirichenko et al., 2022)

Similarly, mitochondria from GPx1 / hearts showed increased production of DCF-detectable reactive oxygen species at baseline, whereas following hypoxia/reoxygenation, both DCF fluorescence and superoxide production (as measured by Mitotracker Red) was augmented

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