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It is naturally available in animal products, but deficiencies can occur due to dietary restrictions, malabsorption issues, or certain health conditions

Interactions between hydroxocobalamin and nitric oxide (NO): evidence for a redox reaction between NO and reduced cobalamin and reversible NO binding to oxidized cobalamin

These studies used doses ranging from 1 mg per day to 30 mg per day administered through various routes (subcutaneous, oral, and intranasal)

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