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10.1016/j.molmed.2012.06.010 71 GgotekA.SkrzydlewskaE

Low levels have been linked with symptoms such as low mood, increased anxiety, irritability, and mood swings

Early time-restricted feeding improves 24-hour glucose levels and affects markers of the circadian clock, aging, and autophagy in humans
Treatment of B6 mice with the GLS1 inhibitor BPTES significantly reduced histological scores in the spinal cord of affected animals, lowered the number of CD4 + T cells, IL-17A and IFN-producing CD4 + T cells in the spinal cord, substantially decreased clinical scores and weight loss, and ameliorated experimental autoimmune encephalomyelitis (47)

Furthermore, it has been found that inhibiting GSH synthesis can enhance the efficacy of immunotherapy, boosting the anti-tumor immune response (17)
