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2.4 Study selection, eligibility criteria, and data extraction Reviewers underwent training at each step of the process, and a pilot screening was conducted to ensure consistency in applying the eligibility criteria

Common side effects include, but may not be limited to: pain or redness at the injection site mild diarrhea pruritus (itching) increased swelling joint pain dizziness headache nervousness or anxiety Serious side effects may include: allergic reactions peripheral vascular thrombosis hypokalemia (low potassium levels) pulmonary edema (fluid build-up around or in the lungs) thrombocytosis congestive heart failure There have been reports of anaphylactic shock and death after the parenteral administration of vitamin B12

It was assumed that one prescription claim would last the whole year

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Materials and methods Drugs and delivery methods Several drugs used in the study, including 5-HTP (5-Hydroxytryptophan), carbidopa (CB), and tesofensine, were kindly donated by Productos Medix (Mexico)