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In human subjects, several studies suggest that high selenium supplementation increases the risk of type 2 diabetes [103, 104], and, in mouse models, increased expression of selenoproteins as well as selenoprotein deficiency was also correlated with metabolic dysregulation [105]
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More recently, in CHD patients undergoing PCI, intravenous administration of probucol (500 mg twice daily, one day before and three days after surgery) increased serum GSH levels [244]
Baltz RH Combinatorial Biosynthesis of Novel Antibiotics Related to Daptomycin
