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The mice were randomly divided into 2 groups: those with early-life exercise (EXE), and those without early-life exercise (SED)

1, 2 This impairment appears to play a role in the pathogenesis of migraines, since two different nutrients that are essential for mitochondrial energy production (i.e., riboflavin 3 and magnesium 4 ) were each shown in randomized controlled trials in the 1990s to be effective for migraine prophylaxis

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Sattler FR, Castaneda-Sceppa C, Binder EF, Schroeder ET, Wang Y, Bhasin S, Kawakubo M, Stewart Y, Yarasheski KE, Ulloor J, Colletti P, Roubenoff R, Azen SP

24 Hyperammonaemia without clinically significant liver injury has been very well studied and is most likely linked to mitochondrial dysfunction