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Complex it with a copper 2+ ion, encapsulate it for stability, and you can push the effective hydrodynamic radius well past the cutoff

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doi: 10.1016/j.clnu.2013.08.011 124 El-BenhawySAMorsiMIFahmyEISoulaMAKhalilFAlZFhArabAR

Cellular oxidative metabolism produces free radicals and organic peroxides as by-products during cellular mitochondrial electron transport or through metal-catalyzed oxidation of metabolites and oxidoreductases ( Moreover, nitric oxide is produced in hypoxic conditions in a respiratory chain reaction, and RNS may trigger reactive species production, such as reactive aldehydes, malondialdehyde (MDA) and 4-hydroxy-2-non-enal (Lamy et al., 1996