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N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

Notably, in this study, vitamin D appears to influence the development of pulmonary fibrosis through multiple biological pathways: vitamin D deficiency not only exacerbates the lung inflammation caused by bleomycin (similar to the effect observed in the case of vitamin C deficiency), but also increases the likelihood of the occurrence of EMT in the lungs, and these are all crucial steps in the pathogenesis of pulmonary fibrosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Tsutsui H., Kinugawa S., Matsushima S

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Lopez Del Amo V., Seco-Cervera M., Garcia-Gimenez J.L., Whitworth A.J., Pallardo F.V., Galindo M.I

380 Deficiency of TFR1 in skeletal muscle results in abnormal blood iron and lipid metabolism, impairing muscle function