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Fat tissue converts testosterone into estrogen, and obesity can lead to decreased levels of a protein called sex hormone binding globulin that binds to estrogen and progesterone, resulting in more unbound (active) hormones

[DOI] [PubMed] [Google Scholar] 356.Gasmi A., Noor S., Menzel A., Doa A., Pivina L., Bjrklund G

Therapy rationale for mineralocorticoid-receptor antagonists, acetazolamide and a switch of therapy in nonresponders in central serous chorioretinopathy

In whales, positive selection of insulin-related genes and circadian regulators supports metabolic balance and cancer resistance
